2O4R

Crystal Structure of Rat Vitamin D Receptor Ligand Binding Domain Complexed with VitIII 17-20E and the NR2 Box of DRIP 205

Summary for 2O4R

• Entry DOI: 10.2210/pdb2o4r/pdb
• Related: 1RJK 1RK3 2O4J
• Descriptor: Vitamin D3 receptor, Peroxisome proliferator-activated receptor-binding protein, (1R,3R,7E,17E)-17-(5-hydroxy-1,5-dimethylhexylidene)-2-methylene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• Functional Keywords: nuclear receptor-ligand complex, hormone-growth factor receptor complex, hormone/growth factor receptor
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Nucleus: P13053 Q15648
• Total number of polymer chains: 2
• Total formula weight: 34969.25

Authors

Vanhooke, J.L.,Benning, M.M.,DeLuca, H.F. (deposition date: 2006-12-04, release date: 2007-01-30, Last modification date: 2023-08-30)

• Primary citation: Vanhooke, J.L.,Tadi, B.P.,Benning, M.M.,Plum, L.A.,Deluca, H.F.; New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D(3) with conformationally restricted side chains: Evaluation of biological activity and structural determination of VDR-bound conformations.; Arch.Biochem.Biophys., 460:161-165, 2007; PubMed: 17227670; DOI: 10.1016/j.abb.2006.11.029

Experimental method

X-RAY DIFFRACTION (1.98 Å)