2O39

Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)

Summary for 2O39

• Entry DOI: 10.2210/pdb2o39/pdb
• Related: 1CKL
• Descriptor: Fiber protein, Membrane cofactor protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: membrane cofactor protein, mcp, cd46, adenovirus, fiber knob, ad11, virus receptor complex, scr, short consensus repeat, ccp, complement control protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human adenovirus 11p; More
• Cellular location: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein: P15529
• Total number of polymer chains: 4
• Total formula weight: 74421.51

Authors

Persson, D.B.,Reiter, D.M.,Arnberg, N.,Stehle, T. (deposition date: 2006-12-01, release date: 2007-01-09, Last modification date: 2024-10-30)

Primary citation

Persson, B.D.,Reiter, D.M.,Marttila, M.,Mei, Y.F.,Casasnovas, J.M.,Arnberg, N.,Stehle, T.
Adenovirus type 11 binding alters the conformation of its receptor CD46.
Nat.Struct.Mol.Biol., 14:164-166, 2007

PubMed Abstract: Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.

PubMed: 17220899
DOI: 10.1038/nsmb1190

Experimental method

X-RAY DIFFRACTION (2.85 Å)