2MPG

Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue

Summary for 2MPG
NMR InformationBMRB: 19978
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordsinsulin analogue, hormone
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5845.70
Authors
Kosinova, L.,Jiracek, J.,Zakova, L.,Veverka, V. (deposition date: 2014-05-17, release date: 2014-06-11, Last modification date: 2015-02-18)
Primary citationBrzozowski, A.M.,Collinsova, M.,Jiracek, J.,Kosinova, L.,Moody, N.R.,Novotna, P.,Turkenburg, J.P.,Urbanova, M.,Veverka, V.,Zakova, L.
Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.
Biochemistry, 53:3392-3402, 2014
PubMed: 24819248
DOI: 110.1021/bi500073z
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-23