2KS1

Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation

Summary for 2KS1

• Entry DOI: 10.2210/pdb2ks1/pdb
• Related: 2jwa
• Descriptor: Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor (2 entities in total)
• Functional Keywords: erbb1, erbb2, transmembrane, heterodimer, complex, tyrosine kinase receptor, bicelles, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P04626; Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P00533
• Total number of polymer chains: 2
• Total formula weight: 9468.65

Authors

Mineev, K.S.,Bocharov, E.V.,Pustovalova, Y.E.,Bocharova, O.V.,Chupin, V.V.,Arseniev, A.S. (deposition date: 2009-12-24, release date: 2010-06-09, Last modification date: 2011-07-13)

• Primary citation: Mineev, K.S.,Bocharov, E.V.,Pustovalova, Y.E.,Bocharova, O.V.,Chupin, V.V.,Arseniev, A.S.; Spatial Structure of the Transmembrane Domain Heterodimer of ErbB1 and ErbB2 Receptor Tyrosine Kinases; J.Mol.Biol., 2010; PubMed: 20471394; DOI: 10.1016/j.jmb.2010.05.016

Experimental method

SOLUTION NMR