Enhancing the activity of insulin by stereospecific unfolding

Summary for 2K91
NMR InformationBMRB: 16027
DescriptorInsulin (2 entities in total)
Functional Keywordshormone, insulin, mutant, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, pharmaceutical, secreted
Biological sourceHomo sapiens
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5718.50
Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakarawa, S.,Jia, W.H.,Philips, N.F.P.,Wittaker, L.,Wittaker, J.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2008-09-29, release date: 2008-11-18, Last modification date: 2011-07-13)
Primary citationHu, S.Q.,Hua, Q.X.,Huang, K.,Jia, W.,Katsoyannis, P.G.,Nakagawa, S.,Wang, S.,Weiss, M.A.,Whittaker, J.,Xu, B.
Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284:14586-14596, 2009
PubMed: 19321436
DOI: 110.1074/jbc.M900085200
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-23