2K91

Enhancing the activity of insulin by stereospecific unfolding

Summary for 2K91
NMR InformationBMRB: 16027
DescriptorInsulin (2 entities in total)
Functional Keywordshormone, insulin, mutant, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, pharmaceutical, secreted
Biological sourceHomo sapiens
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Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5718.50
Authors
Hua, Q.X.,Xu, B.,Huang, K.,Hu, S.Q.,Nakarawa, S.,Jia, W.H.,Philips, N.F.P.,Wittaker, L.,Wittaker, J.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2008-09-29, release date: 2008-11-18, Last modification date: 2011-07-13)
Primary citationHu, S.Q.,Hua, Q.X.,Huang, K.,Jia, W.,Katsoyannis, P.G.,Nakagawa, S.,Wang, S.,Weiss, M.A.,Whittaker, J.,Xu, B.
Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284:14586-14596, 2009
PubMed: 19321436
DOI: 110.1074/jbc.M900085200
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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179210

PDB entries from 2021-06-23