2K7A
Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase.
Summary for 2K7A
Entry DOI | 10.2210/pdb2k7a/pdb |
Related | 1awj 1luk 1lun 2K79 2etz 2rna |
NMR Information | BMRB: 16809 |
Descriptor | SH3 domain of Tyrosine-protein kinase ITK/TSK, SH2 domain of Tyrosine-protein kinase ITK/TSK (2 entities in total) |
Functional Keywords | sh3, sh2, novel, cis, atp-binding, cell membrane, kinase, membrane, metal-binding, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc, zinc-finger |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 20034.27 |
Authors | Andreotti, A.H.,Severin, A.J.,Fulton, D.B. (deposition date: 2008-08-08, release date: 2009-03-10, Last modification date: 2020-01-01) |
Primary citation | Severin, A.,Joseph, R.E.,Boyken, S.,Fulton, D.B.,Andreotti, A.H. Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain. J.Mol.Biol., 387:726-743, 2009 Cited by PubMed: 19361414DOI: 10.1016/j.jmb.2009.02.012 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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