2K79

Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase

Summary for 2K79

• Entry DOI: 10.2210/pdb2k79/pdb
• Related: 1awj 1luk 1lun 2K7A 2etz 2rna
• NMR Information: BMRB: 15912
• Descriptor: SH3 domain of Tyrosine-protein kinase ITK/TSK, SH2 domain of Tyrosine-protein kinase ITK/TSK (2 entities in total)
• Functional Keywords: sh3, sh2, novel, cis, atp-binding, cell membrane, kinase, membrane, metal-binding, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc, zinc-finger
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 20034.27

Authors

Andreotti, A.H.,Severin, A.J.,Fulton, D.B. (deposition date: 2008-08-08, release date: 2009-03-10, Last modification date: 2020-01-01)

• Primary citation: Severin, A.,Joseph, R.E.,Boyken, S.,Fulton, D.B.,Andreotti, A.H.; Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.; J.Mol.Biol., 387:726-743, 2009; PubMed: 19361414; DOI: 10.1016/j.jmb.2009.02.012

Experimental method

SOLUTION NMR