2K79

Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	SH3 domain of Tyrosine-protein kinase ITK/TSK	polymer	63	7355.9	1	UniProt (Q03526) Pfam (PF00018)	Mus musculus (mouse)	T-cell-specific kinase, IL-2-inducible T-cell kinase, Kinase EMT, Kinase TLK
2	B (B)	SH2 domain of Tyrosine-protein kinase ITK/TSK	polymer	110	12678.3	1	UniProt (Q03526) Pfam (PF00017)	Mus musculus (mouse)	T-cell-specific kinase, IL-2-inducible T-cell kinase, Kinase EMT, Kinase TLK

Sequence modifications

A: 171 - 231 (UniProt: Q03526)

PDB	External Database	Details
Gly 169	-	expression tag
Ser 170	-	expression tag

B: 232 - 338 (UniProt: Q03526)

PDB	External Database	Details
Gly 230	-	expression tag
Ser 231	-	expression tag
Gly 339	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20034.3
All*	Total formula weight	20034.3

*Water molecules are not included.