2K4D

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

Summary for 2K4D

• Entry DOI: 10.2210/pdb2k4d/pdb
• Related: 1FBV
• NMR Information: BMRB: 15796
• Descriptor: E3 ubiquitin-protein ligase CBL, ZINC ION (2 entities in total)
• Functional Keywords: protein, ubiquitin, c-cbl, ubch5b, ubch7, calcium, cytoplasm, ligase, metal-binding, phosphoprotein, proto-oncogene, sh2 domain, ubl conjugation pathway, zinc, zinc-finger
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 9518.48

Authors

Huang, A.,De Jong, R.N.,Wienk, H.,Winkler, S.G.,Timmers, H.T.M.,Boelens, R. (deposition date: 2008-06-06, release date: 2009-01-20, Last modification date: 2023-06-14)

• Primary citation: Huang, A.,de Jong, R.N.,Wienk, H.,Winkler, G.S.,Timmers, H.T.M.,Boelens, R.; E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity; J.Mol.Biol., 385:507-519, 2009; PubMed: 18996392; DOI: 10.1016/j.jmb.2008.10.044

Experimental method

SOLUTION NMR