2K4D

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0023051	biological_process	regulation of signaling
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 500

Chain	Residue
A	CYS381
A	ILE383
A	CYS384
A	ASN387
A	ASP388

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 600

Chain	Residue
A	ILE393
A	CYS396
A	HIS398
A	CYS421

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Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL

Chain	Residue	Details
A	CYS396-LEU405

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
A	CYS381-ARG420

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497

Chain	Residue	Details
A	TYR371

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