2K04

Structure of SDF1 in complex with the CXCR4 N-terminus containing no sulfotyrosines

Summary for 2K04

• Entry DOI: 10.2210/pdb2k04/pdb
• Related: 2K01 2K03 2K05
• NMR Information: BMRB: 15636
• Descriptor: Stromal cell-derived factor 1, C-X-C chemokine receptor type 4 (2 entities in total)
• Functional Keywords: stromal cell derived factor-1, sdf1-alpha, cxcl12, cxcr4, chemokine, locked dimer, alternative splicing, chemotaxis, cytokine, growth factor, secreted, g-protein coupled receptor, glycoprotein, host-virus interaction, membrane, receptor, sulfation, transducer, transmembrane
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 25415.06

Authors

Volkman, B.F.,Veldkamp, C.T.,Peterson, F.C. (deposition date: 2008-01-24, release date: 2008-10-28, Last modification date: 2023-06-14)

• Primary citation: Veldkamp, C.T.,Seibert, C.,Peterson, F.C.,De la Cruz, N.B.,Haugner, J.C.,Basnet, H.,Sakmar, T.P.,Volkman, B.F.; Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12; Sci.Signal., 1:ra4-ra4, 2008; PubMed: 18799424; DOI: 10.1126/scisignal.1160755

Experimental method

SOLUTION NMR