2K04
Structure of SDF1 in complex with the CXCR4 N-terminus containing no sulfotyrosines
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Stromal cell-derived factor 1 | polymer | 70 | 8188.8 | 2 | UniProt (P48061) Pfam (PF00048) In PDB | Homo sapiens (human) | SDF-1, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, PBSF, hIRH |
| 2 | B, D | C-X-C chemokine receptor type 4 | polymer | 40 | 4518.8 | 2 | UniProt (P61073) Pfam (PF12109) In PDB | Homo sapiens (human) | CXC-R4, CXCR-4, Stromal cell- derived factor 1 receptor, SDF-1 receptor, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, LCR1, FB22, NPYRL, HM89, CD184 antigen |
Sequence modifications
A, C: 1 - 68 (UniProt: P48061)
B, D: 101 - 138 (UniProt: P61073)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Met 0 | - | expression tag |
| Cys 36 | Leu 57 | engineered mutation |
| Cys 65 | Ala 86 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 99 | - | expression tag |
| Ser 100 | - | expression tag |
| Ala 128 | Cys 28 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 25415.1 | |
| All* | Total formula weight | 25415.1 |
