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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2K04

Structure of SDF1 in complex with the CXCR4 N-terminus containing no sulfotyrosines

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001764biological_processneuron migration
A0001938biological_processpositive regulation of endothelial cell proliferation
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006874biological_processintracellular calcium ion homeostasis
A0006935biological_processchemotaxis
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007411biological_processaxon guidance
A0008009molecular_functionchemokine activity
A0008015biological_processblood circulation
A0008064biological_processregulation of actin polymerization or depolymerization
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008344biological_processadult locomotory behavior
A0009612biological_processresponse to mechanical stimulus
A0009615biological_processresponse to virus
A0009897cellular_componentexternal side of plasma membrane
A0016020cellular_componentmembrane
A0022029biological_processtelencephalon cell migration
A0030335biological_processpositive regulation of cell migration
A0031012cellular_componentextracellular matrix
A0031100biological_processanimal organ regeneration
A0033603biological_processpositive regulation of dopamine secretion
A0033622biological_processintegrin activation
A0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
A0038160biological_processCXCL12-activated CXCR4 signaling pathway
A0042379molecular_functionchemokine receptor binding
A0043434biological_processresponse to peptide hormone
A0045236molecular_functionCXCR chemokine receptor binding
A0045666biological_processpositive regulation of neuron differentiation
A0045785biological_processpositive regulation of cell adhesion
A0048842biological_processpositive regulation of axon extension involved in axon guidance
A0050921biological_processpositive regulation of chemotaxis
A0050930biological_processinduction of positive chemotaxis
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051924biological_processregulation of calcium ion transport
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0070098biological_processchemokine-mediated signaling pathway
A0090026biological_processpositive regulation of monocyte chemotaxis
A0090280biological_processpositive regulation of calcium ion import
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1903237biological_processnegative regulation of leukocyte tethering or rolling
A1904018biological_processpositive regulation of vasculature development
A1990478biological_processresponse to ultrasound
A1990869biological_processcellular response to chemokine
A2000406biological_processpositive regulation of T cell migration
A2000669biological_processnegative regulation of dendritic cell apoptotic process
B0016020cellular_componentmembrane
B0019955molecular_functioncytokine binding
C0001666biological_processresponse to hypoxia
C0001764biological_processneuron migration
C0001938biological_processpositive regulation of endothelial cell proliferation
C0005102molecular_functionsignaling receptor binding
C0005125molecular_functioncytokine activity
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006874biological_processintracellular calcium ion homeostasis
C0006935biological_processchemotaxis
C0006955biological_processimmune response
C0007155biological_processcell adhesion
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007411biological_processaxon guidance
C0008009molecular_functionchemokine activity
C0008015biological_processblood circulation
C0008064biological_processregulation of actin polymerization or depolymerization
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0008344biological_processadult locomotory behavior
C0009612biological_processresponse to mechanical stimulus
C0009615biological_processresponse to virus
C0009897cellular_componentexternal side of plasma membrane
C0016020cellular_componentmembrane
C0022029biological_processtelencephalon cell migration
C0030335biological_processpositive regulation of cell migration
C0031012cellular_componentextracellular matrix
C0031100biological_processanimal organ regeneration
C0033603biological_processpositive regulation of dopamine secretion
C0033622biological_processintegrin activation
C0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
C0038160biological_processCXCL12-activated CXCR4 signaling pathway
C0042379molecular_functionchemokine receptor binding
C0043434biological_processresponse to peptide hormone
C0045236molecular_functionCXCR chemokine receptor binding
C0045666biological_processpositive regulation of neuron differentiation
C0045785biological_processpositive regulation of cell adhesion
C0048842biological_processpositive regulation of axon extension involved in axon guidance
C0050921biological_processpositive regulation of chemotaxis
C0050930biological_processinduction of positive chemotaxis
C0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
C0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
C0051924biological_processregulation of calcium ion transport
C0060326biological_processcell chemotaxis
C0070062cellular_componentextracellular exosome
C0070098biological_processchemokine-mediated signaling pathway
C0090026biological_processpositive regulation of monocyte chemotaxis
C0090280biological_processpositive regulation of calcium ion import
C1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
C1903237biological_processnegative regulation of leukocyte tethering or rolling
C1904018biological_processpositive regulation of vasculature development
C1990478biological_processresponse to ultrasound
C1990869biological_processcellular response to chemokine
C2000406biological_processpositive regulation of T cell migration
C2000669biological_processnegative regulation of dendritic cell apoptotic process
D0016020cellular_componentmembrane
D0019955molecular_functioncytokine binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsRegion: {"description":"Receptor and heparin binding","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues28
DetailsRegion: {"description":"Receptor binding"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsMotif: {"description":"Receptor activation motif"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues26
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsSite: {"description":"Important for integrin interaction and activation","evidences":[{"source":"PubMed","id":"29301984","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Important for dimer formation"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues74
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsRegion: {"description":"Important for chemokine binding, signaling and HIV-1 coreceptor activity","evidences":[{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Sulfotyrosine; partial","evidences":[{"source":"PubMed","id":"18834145","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"12034737","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16725153","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18834145","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10756055","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (Xyl...) (chondroitin sulfate) serine","evidences":[{"source":"PubMed","id":"12034737","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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