2IHQ
Crystal Structure of the Rat Androgen Receptor Ligand Binding Domian Complex with an N-Aryl-Hydroxybicyclohydantoin
Summary for 2IHQ
Entry DOI | 10.2210/pdb2ihq/pdb |
Related | 1I37 |
Descriptor | Androgen receptor, 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE (3 entities in total) |
Functional Keywords | androgen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, hormone-growth factor complex, hormone/growth factor |
Biological source | Rattus norvegicus (Norway rat) |
Cellular location | Nucleus: P15207 |
Total number of polymer chains | 1 |
Total formula weight | 30589.72 |
Authors | Sack, J.S. (deposition date: 2006-09-27, release date: 2006-12-12, Last modification date: 2023-08-30) |
Primary citation | Sun, C.,Robl, J.A.,Wang, T.C.,Huang, Y.,Kuhns, J.E.,Lupisella, J.A.,Beehler, B.C.,Golla, R.,Sleph, P.G.,Seethala, R.,Fura, A.,Krystek, S.R.,An, Y.,Malley, M.F.,Sack, J.S.,Salvati, M.E.,Grover, G.J.,Ostrowski, J.,Hamann, L.G. Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold. J.Med.Chem., 49:7596-7599, 2006 Cited by PubMed: 17181141DOI: 10.1021/jm061101w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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