2I40
Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor
Summary for 2I40
Entry DOI | 10.2210/pdb2i40/pdb |
Related | 1FIN |
Descriptor | Cell division protein kinase 2, Cyclin-A2, 5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | cdk2, cyclin, kinase, transferase-cell cycle complex, transferase/cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P20248 |
Total number of polymer chains | 4 |
Total formula weight | 128603.86 |
Authors | Shewchuk, L.M. (deposition date: 2006-08-21, release date: 2006-10-10, Last modification date: 2023-08-30) |
Primary citation | Bamborough, P.,Christopher, J.A.,Cutler, G.J.,Dickson, M.C.,Mellor, G.W.,Morey, J.V.,Patel, C.B.,Shewchuk, L.M. 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase Bioorg.Med.Chem.Lett., 16:6236-6240, 2006 Cited by PubMed: 16997559DOI: 10.1016/j.bmcl.2006.09.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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