2I40

Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cell division protein kinase 2	polymer	298	33976.5	2	UniProt (P24941) Pfam (PF00069)	Homo sapiens (human)	p33 protein kinase
2	B, D (B, D)	Cyclin-A2	polymer	260	29867.5	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	Homo sapiens (human)	Cyclin-A
3	E, F (A, C)	5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE	non-polymer		457.9	2	Chemie (BLZ)
4	G, H, I, J (A, B, C, D)	water	water		18.0	242	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127688.0
Non-Polymers*	Number of molecules	2
	Total formula weight	915.9
All*	Total formula weight	128603.9

*Water molecules are not included.