2HZY
Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate
Summary for 2HZY
Entry DOI | 10.2210/pdb2hzy/pdb |
Related | 1HYO 1QCN 1QCO 1QQJ |
Descriptor | Fumarylacetoacetase, SODIUM ION, MANGANESE (II) ION, ... (7 entities in total) |
Functional Keywords | transition-state mimicking complex, hydrolase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 2 |
Total formula weight | 93852.45 |
Authors | Hurley, T.D.,Timm, D.E. (deposition date: 2006-08-09, release date: 2006-08-22, Last modification date: 2023-08-30) |
Primary citation | Bateman, R.L.,Ashworth, J.,Witte, J.F.,Baker, L.J.,Bhanumoorthy, P.,Timm, D.E.,Hurley, T.D.,Grompe, M.,McClard, R.W. Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics. Biochem.J., 402:251-260, 2007 Cited by PubMed: 17064256DOI: 10.1042/BJ20060961 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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