2HU4
N1 neuraminidase in complex with oseltamivir 2
Summary for 2HU4
Entry DOI | 10.2210/pdb2hu4/pdb |
Related | 2HT5 2HT7 2HT8 2HTQ 2HTR 2HTU 2HTV 2HTW 2HTY 2HU0 |
Descriptor | Neuraminidase, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid (2 entities in total) |
Functional Keywords | n1, neuraminidase, oseltamivir, hydrolase |
Biological source | Influenza A virus |
Cellular location | Host apical cell membrane ; Single-pass type II membrane protein : Q6DPL2 |
Total number of polymer chains | 8 |
Total formula weight | 341708.25 |
Authors | Russell, R.J.,Haire, L.F.,Stevens, D.J.,Collins, P.J.,Lin, Y.P.,Blackburn, G.M.,Hay, A.J.,Gamblin, S.J.,Skehel, J.J. (deposition date: 2006-07-26, release date: 2006-09-05, Last modification date: 2018-02-14) |
Primary citation | Russell, R.J.,Haire, L.F.,Stevens, D.J.,Collins, P.J.,Lin, Y.P.,Blackburn, G.M.,Hay, A.J.,Gamblin, S.J.,Skehel, J.J. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443:45-49, 2006 Cited by PubMed: 16915235DOI: 10.1038/nature05114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report