2HU4
N1 neuraminidase in complex with oseltamivir 2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004308 | molecular_function | exo-alpha-sialidase activity |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0016020 | cellular_component | membrane |
A | 0033644 | cellular_component | host cell membrane |
A | 0046761 | biological_process | viral budding from plasma membrane |
A | 0055036 | cellular_component | virion membrane |
B | 0004308 | molecular_function | exo-alpha-sialidase activity |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0016020 | cellular_component | membrane |
B | 0033644 | cellular_component | host cell membrane |
B | 0046761 | biological_process | viral budding from plasma membrane |
B | 0055036 | cellular_component | virion membrane |
C | 0004308 | molecular_function | exo-alpha-sialidase activity |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0016020 | cellular_component | membrane |
C | 0033644 | cellular_component | host cell membrane |
C | 0046761 | biological_process | viral budding from plasma membrane |
C | 0055036 | cellular_component | virion membrane |
D | 0004308 | molecular_function | exo-alpha-sialidase activity |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0016020 | cellular_component | membrane |
D | 0033644 | cellular_component | host cell membrane |
D | 0046761 | biological_process | viral budding from plasma membrane |
D | 0055036 | cellular_component | virion membrane |
E | 0004308 | molecular_function | exo-alpha-sialidase activity |
E | 0005975 | biological_process | carbohydrate metabolic process |
E | 0016020 | cellular_component | membrane |
E | 0033644 | cellular_component | host cell membrane |
E | 0046761 | biological_process | viral budding from plasma membrane |
E | 0055036 | cellular_component | virion membrane |
F | 0004308 | molecular_function | exo-alpha-sialidase activity |
F | 0005975 | biological_process | carbohydrate metabolic process |
F | 0016020 | cellular_component | membrane |
F | 0033644 | cellular_component | host cell membrane |
F | 0046761 | biological_process | viral budding from plasma membrane |
F | 0055036 | cellular_component | virion membrane |
G | 0004308 | molecular_function | exo-alpha-sialidase activity |
G | 0005975 | biological_process | carbohydrate metabolic process |
G | 0016020 | cellular_component | membrane |
G | 0033644 | cellular_component | host cell membrane |
G | 0046761 | biological_process | viral budding from plasma membrane |
G | 0055036 | cellular_component | virion membrane |
H | 0004308 | molecular_function | exo-alpha-sialidase activity |
H | 0005975 | biological_process | carbohydrate metabolic process |
H | 0016020 | cellular_component | membrane |
H | 0033644 | cellular_component | host cell membrane |
H | 0046761 | biological_process | viral budding from plasma membrane |
H | 0055036 | cellular_component | virion membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE G39 A 800 |
Chain | Residue |
A | ARG118 |
A | ASN294 |
A | TYR347 |
A | ARG371 |
A | TYR406 |
A | GLU119 |
A | ASP151 |
A | ARG152 |
A | TRP178 |
A | SER246 |
A | GLU276 |
A | GLU277 |
A | ARG292 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE G39 B 801 |
Chain | Residue |
B | ARG118 |
B | GLU119 |
B | ASP151 |
B | ARG152 |
B | SER246 |
B | GLU276 |
B | GLU277 |
B | ARG292 |
B | ASN294 |
B | TYR347 |
B | ARG371 |
B | TYR406 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE G39 C 802 |
Chain | Residue |
C | ARG118 |
C | GLU119 |
C | ASP151 |
C | ARG152 |
C | TRP178 |
C | SER246 |
C | GLU276 |
C | GLU277 |
C | ARG292 |
C | ASN294 |
C | TYR347 |
C | ARG371 |
C | TYR406 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE G39 D 803 |
Chain | Residue |
D | ARG118 |
D | GLU119 |
D | ASP151 |
D | ARG152 |
D | ARG224 |
D | SER246 |
D | GLU276 |
D | ARG292 |
D | TYR347 |
D | ARG371 |
D | TYR406 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE G39 E 804 |
Chain | Residue |
E | ARG118 |
E | GLU119 |
E | ASP151 |
E | ARG152 |
E | ARG224 |
E | GLU276 |
E | ARG292 |
E | ASN294 |
E | TYR347 |
E | ARG371 |
E | TYR406 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE G39 F 805 |
Chain | Residue |
F | ARG118 |
F | GLU119 |
F | ASP151 |
F | ARG152 |
F | SER246 |
F | GLU276 |
F | GLU277 |
F | ARG292 |
F | ASN294 |
F | TYR347 |
F | ARG371 |
F | TYR406 |
site_id | AC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE G39 G 806 |
Chain | Residue |
G | ARG118 |
G | GLU119 |
G | ASP151 |
G | ARG152 |
G | ARG224 |
G | GLU276 |
G | GLU277 |
G | ARG292 |
G | TYR347 |
G | ARG371 |
G | TYR406 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE G39 H 807 |
Chain | Residue |
H | GLU119 |
H | ASP151 |
H | ARG152 |
H | ARG224 |
H | GLU276 |
H | GLU277 |
H | ARG292 |
H | TYR347 |
H | ARG371 |
H | TYR406 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071 |
Chain | Residue | Details |
A | ASP151 | |
B | ASP151 | |
C | ASP151 | |
D | ASP151 | |
E | ASP151 | |
F | ASP151 | |
G | ASP151 | |
H | ASP151 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071 |
Chain | Residue | Details |
A | TYR406 | |
B | TYR406 | |
C | TYR406 | |
D | TYR406 | |
E | TYR406 | |
F | TYR406 | |
G | TYR406 | |
H | TYR406 |
site_id | SWS_FT_FI3 |
Number of Residues | 40 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071 |
Chain | Residue | Details |
A | ARG118 | |
B | ARG371 | |
C | ARG118 | |
C | ARG152 | |
C | GLU276 | |
C | ARG292 | |
C | ARG371 | |
D | ARG118 | |
D | ARG152 | |
D | GLU276 | |
D | ARG292 | |
A | ARG152 | |
D | ARG371 | |
E | ARG118 | |
E | ARG152 | |
E | GLU276 | |
E | ARG292 | |
E | ARG371 | |
F | ARG118 | |
F | ARG152 | |
F | GLU276 | |
F | ARG292 | |
A | GLU276 | |
F | ARG371 | |
G | ARG118 | |
G | ARG152 | |
G | GLU276 | |
G | ARG292 | |
G | ARG371 | |
H | ARG118 | |
H | ARG152 | |
H | GLU276 | |
H | ARG292 | |
A | ARG292 | |
H | ARG371 | |
A | ARG371 | |
B | ARG118 | |
B | ARG152 | |
B | GLU276 | |
B | ARG292 |
site_id | SWS_FT_FI4 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 |
Chain | Residue | Details |
A | ASP293 | |
D | ASP293 | |
D | GLY297 | |
D | ASP324 | |
E | ASP293 | |
E | GLY297 | |
E | ASP324 | |
F | ASP293 | |
F | GLY297 | |
F | ASP324 | |
G | ASP293 | |
A | GLY297 | |
G | GLY297 | |
G | ASP324 | |
H | ASP293 | |
H | GLY297 | |
H | ASP324 | |
A | ASP324 | |
B | ASP293 | |
B | GLY297 | |
B | ASP324 | |
C | ASP293 | |
C | GLY297 | |
C | ASP324 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 |
Chain | Residue | Details |
A | GLY345 | |
B | GLY345 | |
C | GLY345 | |
D | GLY345 | |
E | GLY345 | |
F | GLY345 | |
G | GLY345 | |
H | GLY345 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ |
Chain | Residue | Details |
A | TYR347 | |
B | TYR347 | |
C | TYR347 | |
D | TYR347 | |
E | TYR347 | |
F | TYR347 | |
G | TYR347 | |
H | TYR347 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
A | ASP151 | |
A | GLU277 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
B | ASP151 | |
B | GLU277 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
C | ASP151 | |
C | GLU277 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
D | ASP151 | |
D | GLU277 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
E | ASP151 | |
E | GLU277 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
F | ASP151 | |
F | GLU277 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
G | ASP151 | |
G | GLU277 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
H | ASP151 | |
H | GLU277 |