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2HA6

Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with succinylcholine

Summary for 2HA6
Entry DOI10.2210/pdb2ha6/pdb
Related1J06 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA7
DescriptorAcetylcholinesterase, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), HEXAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywordshydrolase fold, serine esterase, acetylcholinesterase, mutant, homodimer, glycosylated protein, hydrolase
Biological sourceMus musculus (house mouse)
Cellular locationCell junction, synapse. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side: P21836
Total number of polymer chains2
Total formula weight121000.96
Authors
Bourne, Y.,Radic, Z.,Sulzenbacher, G.,Kim, E.,Taylor, P.,Marchot, P. (deposition date: 2006-06-12, release date: 2006-07-18, Last modification date: 2023-10-25)
Primary citationBourne, Y.,Radic, Z.,Sulzenbacher, G.,Kim, E.,Taylor, P.,Marchot, P.
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding
J.Biol.Chem., 281:29256-29267, 2006
Cited by
PubMed: 16837465
DOI: 10.1074/jbc.M603018200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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