2H8H

Src kinase in complex with a quinazoline inhibitor

Summary for 2H8H

Entry DOI	10.2210/pdb2h8h/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE (3 entities in total)
Functional Keywords	src kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P12931
Total number of polymer chains	1
Total formula weight	60397.38
Authors	Otterbein, L.R.,Norman, R.,Pauptit, R.A.,Rowsell, S.,Breed, J. (deposition date: 2006-06-07, release date: 2006-11-21, Last modification date: 2024-04-03)
Primary citation	Hennequin, L.F.,Allen, J.,Breed, J.,Curwen, J.,Fennell, M.,Green, T.P.,Lambert-van der Brempt, C.,Morgentin, R.,Norman, R.A.,Olivier, A.,Otterbein, L.,Ple, P.A.,Warin, N.,Costello, G. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J.Med.Chem., 49:6465-6488, 2006 Cited by PubMed: 17064066 DOI: 10.1021/jm060434q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation