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2H8H

Src kinase in complex with a quinazoline inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000166molecular_functionnucleotide binding
A0002102cellular_componentpodosome
A0002223biological_processstimulatory C-type lectin receptor signaling pathway
A0002283biological_processneutrophil activation involved in immune response
A0002376biological_processimmune system process
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005102molecular_functionsignaling receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005764cellular_componentlysosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0006468biological_processprotein phosphorylation
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007172biological_processsignal complex assembly
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007229biological_processintegrin-mediated signaling pathway
A0010632biological_processregulation of epithelial cell migration
A0010634biological_processpositive regulation of epithelial cell migration
A0010954biological_processpositive regulation of protein processing
A0016004molecular_functionphospholipase activator activity
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016301molecular_functionkinase activity
A0016477biological_processcell migration
A0016579biological_processprotein deubiquitination
A0016740molecular_functiontransferase activity
A0018108biological_processpeptidyl-tyrosine phosphorylation
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0020037molecular_functionheme binding
A0022407biological_processregulation of cell-cell adhesion
A0030054cellular_componentcell junction
A0030154biological_processcell differentiation
A0030168biological_processplatelet activation
A0030296molecular_functionprotein tyrosine kinase activator activity
A0030546molecular_functionsignaling receptor activator activity
A0030900biological_processforebrain development
A0031295biological_processT cell costimulation
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031648biological_processprotein destabilization
A0031669biological_processcellular response to nutrient levels
A0032205biological_processnegative regulation of telomere maintenance
A0032587cellular_componentruffle membrane
A0033146biological_processregulation of intracellular estrogen receptor signaling pathway
A0033625biological_processpositive regulation of integrin activation
A0034138biological_processtoll-like receptor 3 signaling pathway
A0034139biological_processregulation of toll-like receptor 3 signaling pathway
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0034614biological_processcellular response to reactive oxygen species
A0035255molecular_functionionotropic glutamate receptor binding
A0035306biological_processpositive regulation of dephosphorylation
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0036035biological_processosteoclast development
A0036120biological_processcellular response to platelet-derived growth factor stimulus
A0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
A0038128biological_processERBB2 signaling pathway
A0038166biological_processangiotensin-activated signaling pathway
A0038202biological_processTORC1 signaling
A0042169molecular_functionSH2 domain binding
A0042311biological_processvasodilation
A0042476biological_processodontogenesis
A0043066biological_processnegative regulation of apoptotic process
A0043114biological_processregulation of vascular permeability
A0043149biological_processstress fiber assembly
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043274molecular_functionphospholipase binding
A0044325molecular_functiontransmembrane transporter binding
A0045121cellular_componentmembrane raft
A0045124biological_processregulation of bone resorption
A0045296molecular_functioncadherin binding
A0045453biological_processbone resorption
A0045747biological_processpositive regulation of Notch signaling pathway
A0045821biological_processpositive regulation of glycolytic process
A0046718biological_processsymbiont entry into host cell
A0046777biological_processprotein autophosphorylation
A0046875molecular_functionephrin receptor binding
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048013biological_processephrin receptor signaling pathway
A0048041biological_processfocal adhesion assembly
A0048471cellular_componentperinuclear region of cytoplasm
A0048477biological_processoogenesis
A0050847biological_processprogesterone receptor signaling pathway
A0050900biological_processleukocyte migration
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0051117molecular_functionATPase binding
A0051219molecular_functionphosphoprotein binding
A0051895biological_processnegative regulation of focal adhesion assembly
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051902biological_processnegative regulation of mitochondrial depolarization
A0060065biological_processuterus development
A0060444biological_processbranching involved in mammary gland duct morphogenesis
A0060491biological_processregulation of cell projection assembly
A0060576biological_processintestinal epithelial cell development
A0070062cellular_componentextracellular exosome
A0070102biological_processinterleukin-6-mediated signaling pathway
A0070161cellular_componentanchoring junction
A0070301biological_processcellular response to hydrogen peroxide
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070555biological_processresponse to interleukin-1
A0070700molecular_functionBMP receptor binding
A0071253molecular_functionconnexin binding
A0071375biological_processcellular response to peptide hormone stimulus
A0071393biological_processcellular response to progesterone stimulus
A0071498biological_processcellular response to fluid shear stress
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0071803biological_processpositive regulation of podosome assembly
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0086091biological_processregulation of heart rate by cardiac conduction
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0097110molecular_functionscaffold protein binding
A1900182biological_processpositive regulation of protein localization to nucleus
A1902564biological_processnegative regulation of neutrophil activation
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A2000394biological_processpositive regulation of lamellipodium morphogenesis
A2000588biological_processpositive regulation of platelet-derived growth factor receptor-beta signaling pathway
A2000641biological_processregulation of early endosome to late endosome transport
A2000811biological_processnegative regulation of anoikis
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
A2001286biological_processregulation of caveolin-mediated endocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE H8H A 534
ChainResidue
ALEU273
AGLY344
ALEU393
AASP404
AHOH543
AVAL281
AALA293
ALYS295
ATHR338
AGLU339
ATYR340
AMET341
ASER342

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK
ChainResidueDetails
ALEU273-LYS295

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV
ChainResidueDetails
ATYR382-VAL394

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues97
DetailsDomain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues253
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues9
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05480","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by FAK2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"19307596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26936507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7525268","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7929427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP386
AALA390

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AARG388
AASP386

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AARG388
AASN391
AASP386

239492

PDB entries from 2025-07-30

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