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2H8H

Src kinase in complex with a quinazoline inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001545biological_processprimary ovarian follicle growth
A0001819biological_processpositive regulation of cytokine production
A0002102cellular_componentpodosome
A0002223biological_processstimulatory C-type lectin receptor signaling pathway
A0002376biological_processimmune system process
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005080molecular_functionprotein kinase C binding
A0005102molecular_functionsignaling receptor binding
A0005158molecular_functioninsulin receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005764cellular_componentlysosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0005925cellular_componentfocal adhesion
A0006468biological_processprotein phosphorylation
A0007049biological_processcell cycle
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007172biological_processsignal complex assembly
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007229biological_processintegrin-mediated signaling pathway
A0007283biological_processspermatogenesis
A0007611biological_processlearning or memory
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0010447biological_processresponse to acidic pH
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010632biological_processregulation of epithelial cell migration
A0010634biological_processpositive regulation of epithelial cell migration
A0010907biological_processpositive regulation of glucose metabolic process
A0010954biological_processpositive regulation of protein processing
A0014856biological_processskeletal muscle cell proliferation
A0014911biological_processpositive regulation of smooth muscle cell migration
A0016004molecular_functionphospholipase activator activity
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016477biological_processcell migration
A0016740molecular_functiontransferase activity
A0018108biological_processpeptidyl-tyrosine phosphorylation
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0020037molecular_functionheme binding
A0022407biological_processregulation of cell-cell adhesion
A0030054cellular_componentcell junction
A0030154biological_processcell differentiation
A0030168biological_processplatelet activation
A0030331molecular_functionnuclear estrogen receptor binding
A0030900biological_processforebrain development
A0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
A0031295biological_processT cell costimulation
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031648biological_processprotein destabilization
A0031667biological_processresponse to nutrient levels
A0032211biological_processnegative regulation of telomere maintenance via telomerase
A0032587cellular_componentruffle membrane
A0032869biological_processcellular response to insulin stimulus
A0033146biological_processregulation of intracellular estrogen receptor signaling pathway
A0033625biological_processpositive regulation of integrin activation
A0034139biological_processregulation of toll-like receptor 3 signaling pathway
A0034332biological_processadherens junction organization
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0034614biological_processcellular response to reactive oxygen species
A0035306biological_processpositive regulation of dephosphorylation
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0035635biological_processentry of bacterium into host cell
A0036035biological_processosteoclast development
A0036120biological_processcellular response to platelet-derived growth factor stimulus
A0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
A0038128biological_processERBB2 signaling pathway
A0038166biological_processangiotensin-activated signaling pathway
A0042169molecular_functionSH2 domain binding
A0042476biological_processodontogenesis
A0042542biological_processresponse to hydrogen peroxide
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043114biological_processregulation of vascular permeability
A0043149biological_processstress fiber assembly
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043274molecular_functionphospholipase binding
A0044294cellular_componentdendritic growth cone
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045056biological_processtranscytosis
A0045087biological_processinnate immune response
A0045121cellular_componentmembrane raft
A0045124biological_processregulation of bone resorption
A0045296molecular_functioncadherin binding
A0045453biological_processbone resorption
A0045747biological_processpositive regulation of Notch signaling pathway
A0045780biological_processpositive regulation of bone resorption
A0045785biological_processpositive regulation of cell adhesion
A0046579biological_processpositive regulation of Ras protein signal transduction
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046777biological_processprotein autophosphorylation
A0046875molecular_functionephrin receptor binding
A0048008biological_processplatelet-derived growth factor receptor signaling pathway
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048011biological_processneurotrophin TRK receptor signaling pathway
A0048013biological_processephrin receptor signaling pathway
A0048041biological_processfocal adhesion assembly
A0048471cellular_componentperinuclear region of cytoplasm
A0048477biological_processoogenesis
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050839molecular_functioncell adhesion molecule binding
A0050847biological_processprogesterone receptor signaling pathway
A0050900biological_processleukocyte migration
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0051117molecular_functionATPase binding
A0051219molecular_functionphosphoprotein binding
A0051222biological_processpositive regulation of protein transport
A0051385biological_processresponse to mineralocorticoid
A0051450biological_processmyoblast proliferation
A0051602biological_processresponse to electrical stimulus
A0051895biological_processnegative regulation of focal adhesion assembly
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051902biological_processnegative regulation of mitochondrial depolarization
A0051974biological_processnegative regulation of telomerase activity
A0060065biological_processuterus development
A0060444biological_processbranching involved in mammary gland duct morphogenesis
A0060491biological_processregulation of cell projection assembly
A0060576biological_processintestinal epithelial cell development
A0070062cellular_componentextracellular exosome
A0070102biological_processinterleukin-6-mediated signaling pathway
A0070161cellular_componentanchoring junction
A0070301biological_processcellular response to hydrogen peroxide
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070542biological_processresponse to fatty acid
A0070555biological_processresponse to interleukin-1
A0070700molecular_functionBMP receptor binding
A0071222biological_processcellular response to lipopolysaccharide
A0071253molecular_functionconnexin binding
A0071375biological_processcellular response to peptide hormone stimulus
A0071393biological_processcellular response to progesterone stimulus
A0071398biological_processcellular response to fatty acid
A0071456biological_processcellular response to hypoxia
A0071498biological_processcellular response to fluid shear stress
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0071803biological_processpositive regulation of podosome assembly
A0071897biological_processDNA biosynthetic process
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0086091biological_processregulation of heart rate by cardiac conduction
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0097060cellular_componentsynaptic membrane
A0097110molecular_functionscaffold protein binding
A0098609biological_processcell-cell adhesion
A0098978cellular_componentglutamatergic synapse
A0099091cellular_componentpostsynaptic specialization, intracellular component
A1900182biological_processpositive regulation of protein localization to nucleus
A1902533biological_processpositive regulation of intracellular signal transduction
A1902737cellular_componentdendritic filopodium
A1903997biological_processpositive regulation of non-membrane spanning protein tyrosine kinase activity
A1904263biological_processpositive regulation of TORC1 signaling
A1904385biological_processcellular response to angiotensin
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A1990646biological_processcellular response to prolactin
A2000256biological_processpositive regulation of male germ cell proliferation
A2000386biological_processpositive regulation of ovarian follicle development
A2000394biological_processpositive regulation of lamellipodium morphogenesis
A2000588biological_processpositive regulation of platelet-derived growth factor receptor-beta signaling pathway
A2000641biological_processregulation of early endosome to late endosome transport
A2000811biological_processnegative regulation of anoikis
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
A2001286biological_processregulation of caveolin-mediated endocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE H8H A 534
ChainResidue
ALEU273
AGLY344
ALEU393
AASP404
AHOH543
AVAL281
AALA293
ALYS295
ATHR338
AGLU339
ATYR340
AMET341
ASER342

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK
ChainResidueDetails
ALEU273-LYS295

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV
ChainResidueDetails
ATYR382-VAL394

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ALEU387

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
ATHR296
AGLY274

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ALEU15

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5 => ECO:0000269|PubMed:21442427, ECO:0007744|PubMed:23186163
ChainResidueDetails
APRO73

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05480
ChainResidueDetails
ACYS185

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by FAK2 => ECO:0000250
ChainResidueDetails
ATHR417

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by CSK => ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:26936507, ECO:0000269|PubMed:7525268, ECO:0000269|PubMed:7929427, ECO:0007744|PubMed:19369195
ChainResidueDetails
AGLN528

site_idSWS_FT_FI8
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:7525268
ChainResidueDetails
ASER0

218500

PDB entries from 2024-04-17

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