2GTN
Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717
Summary for 2GTN
Entry DOI | 10.2210/pdb2gtn/pdb |
Related | 1yw2 1ywr 2ghl 2ghm |
Descriptor | Mitogen-activated protein kinase 14, SULFATE ION, 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE, ... (4 entities in total) |
Functional Keywords | map kinase p38, p38, transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm : P47811 |
Total number of polymer chains | 1 |
Total formula weight | 40396.09 |
Authors | Walter, R.L.,Mekel, M.J.,Evdokimov, A.G.,Pokross, M.E.,Sabat, M. (deposition date: 2006-04-28, release date: 2006-07-11, Last modification date: 2024-04-03) |
Primary citation | Sabat, M.,Vanrens, J.C.,Clark, M.P.,Brugel, T.A.,Maier, J.,Bookland, R.G.,Laufersweiler, M.J.,Laughlin, S.K.,Golebiowski, A.,De, B.,Hsieh, L.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J. The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. Bioorg.Med.Chem.Lett., 16:4360-4365, 2006 Cited by PubMed: 16750367DOI: 10.1016/j.bmcl.2006.05.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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