2GK1
X-ray crystal structure of NGT-bound HexA
Summary for 2GK1
Entry DOI | 10.2210/pdb2gk1/pdb |
Related | 2GJX |
Descriptor | Beta-hexosaminidase subunit alpha, Beta-hexosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, ... (9 entities in total) |
Functional Keywords | beta-hexoasaminidase a, glycosidase, tay-sachs disease, sandhoff disease, nag-thazoline, gm2 gangliodosis, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 20 |
Total formula weight | 455559.71 |
Authors | Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N. (deposition date: 2006-03-31, release date: 2006-05-30, Last modification date: 2020-07-29) |
Primary citation | Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N. Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis. J.Mol.Biol., 359:913-929, 2006 Cited by PubMed: 16698036DOI: 10.1016/j.jmb.2006.04.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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