2FMZ

Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine.

Summary for 2FMZ

• Entry DOI: 10.2210/pdb2fmz/pdb
• Related: 2FMG
• Descriptor: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
• Functional Keywords: carbonic anhydrase, activators, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 29720.25

Authors

Temperini, C.,Scozzafava, A.,Vullo, D.,Supuran, C.T. (deposition date: 2006-01-10, release date: 2006-05-23, Last modification date: 2024-02-14)

• Primary citation: Temperini, C.,Scozzafava, A.,Vullo, D.,Supuran, C.T.; Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, VA, VII, and XIV with l- and d-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition within the Active Site of an Enzyme and Its Consequences for the Drug Design.; J.Med.Chem., 49:3019-3027, 2006; PubMed: 16686544; DOI: 10.1021/jm0603320

Experimental method

X-RAY DIFFRACTION (1.6 Å)