2FMG
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine
Summary for 2FMG
Entry DOI | 10.2210/pdb2fmg/pdb |
Related | 2FMZ |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase ii, activators, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29720.25 |
Authors | Temperini, C.,Scozzafava, A.,Vullo, D.,Supuran, C.T. (deposition date: 2006-01-09, release date: 2006-05-23, Last modification date: 2024-02-14) |
Primary citation | Temperini, C.,Scozzafava, A.,Vullo, D.,Supuran, C.T. Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, VA, VII, and XIV with l- and d-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition within the Active Site of an Enzyme and Its Consequences for the Drug Design. J.Med.Chem., 49:3019-3027, 2006 Cited by PubMed: 16686544DOI: 10.1021/jm0603320 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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