2FI3

Crystal structure of a BPTI variant (Cys14->Ser, Cys38->Ser) in complex with trypsin

Summary for 2FI3

• Entry DOI: 10.2210/pdb2fi3/pdb
• Related: 2FI4 2FI5 2PTC
• Descriptor: Cationic trypsin, Pancreatic trypsin inhibitor, SODIUM ION, ... (7 entities in total)
• Functional Keywords: protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Bos taurus (cattle); More
• Cellular location: Secreted, extracellular space: P00760; Secreted: P00974
• Total number of polymer chains: 2
• Total formula weight: 31063.78

Authors

Zakharova, E.,Horvath, M.P.,Goldenberg, D.P. (deposition date: 2005-12-27, release date: 2006-01-24, Last modification date: 2023-08-30)

• Primary citation: Zakharova, E.,Horvath, M.P.,Goldenberg, D.P.; Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.; J.Mol.Biol., 382:998-1013, 2008; PubMed: 18692070; DOI: 10.1016/j.jmb.2008.07.063

Experimental method

X-RAY DIFFRACTION (1.58 Å)