2FI3
Crystal structure of a BPTI variant (Cys14->Ser, Cys38->Ser) in complex with trypsin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Cationic trypsin | polymer | 223 | 23324.3 | 1 | UniProt (P00760) Pfam (PF00089) | Bos taurus (cattle) | Beta-trypsin |
| 2 | B (I) | Pancreatic trypsin inhibitor | polymer | 58 | 6495.4 | 1 | UniProt (P00974) Pfam (PF00014) | Bos taurus (cattle) | Basic protease inhibitor, BPI, BPTI, Aprotinin |
| 3 | C (E) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | D, M (E, I) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | E, F, N, O, P... (E, I) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 6 | G, H, I, J, K... (E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 7 | T, U (E, I) | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
I: 1 - 58 (UniProt: P00974)
| PDB | External Database | Details |
|---|---|---|
| Ser 14 | Cys 49 | engineered mutation |
| Ser 38 | Cys 73 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29819.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1244.1 | |
| All* | Total formula weight | 31063.8 |
