2FAP

THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA

Summary for 2FAP

Entry DOI	10.2210/pdb2fap/pdb
Descriptor	FK506-BINDING PROTEIN, FRAP, C49-METHYL RAPAMYCIN, ... (4 entities in total)
Functional Keywords	fkbp12, frap, rapamycin, complex (isomerase-kinase), complex (isomerase-kinase) complex, complex (isomerase/kinase)
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P62942 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345
Total number of polymer chains	2
Total formula weight	24096.64
Authors	Liang, J.,Choi, J.,Clardy, J. (deposition date: 1998-09-22, release date: 1999-05-18, Last modification date: 2023-08-09)
Primary citation	Liang, J.,Choi, J.,Clardy, J. Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr.,Sect.D, 55:736-744, 1999 Cited by PubMed: 10089303 DOI: 10.1107/S0907444998014747 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation