2EWA
Dual binding mode of pyridinylimidazole to MAP kinase p38
Summary for 2EWA
Entry DOI | 10.2210/pdb2ewa/pdb |
Descriptor | Mitogen-activated protein kinase 14, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE (3 entities in total) |
Functional Keywords | map kinase, dfg out, transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm: P47811 |
Total number of polymer chains | 1 |
Total formula weight | 43760.79 |
Authors | Delarbre, L.,Pouzieux, S.,Guilloteau, J.-P.,Michot, N. (deposition date: 2005-11-02, release date: 2006-08-01, Last modification date: 2024-02-14) |
Primary citation | Vogtherr, M.,Saxena, K.,Hoelder, S.,Grimme, S.,Betz, M.,Schieborr, U.,Pescatore, B.,Robin, M.,Delarbre, L.,Langer, T.,Wendt, K.U.,Schwalbe, H. NMR characterization of kinase p38 dynamics in free and ligand-bound forms. Angew.Chem.Int.Ed.Engl., 45:993-997, 2006 Cited by PubMed: 16374788DOI: 10.1002/anie.200502770 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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