2EWA
Dual binding mode of pyridinylimidazole to MAP kinase p38
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 379 | 43383.4 | 1 | UniProt (P47811) Pfam (PF00069) | Mus musculus (house mouse) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, CRK1 |
| 2 | B (A) | 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE | non-polymer | 377.4 | 1 | Chemie (SB2) | |||
| 3 | C (A) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P47811)
| PDB | External Database | Details |
|---|---|---|
| Gly -18 | - | cloning artifact |
| Ser -17 | - | cloning artifact |
| Ser -16 | - | cloning artifact |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| Gly -7 | - | cloning artifact |
| Leu -6 | - | cloning artifact |
| Val -5 | - | cloning artifact |
| Pro -4 | - | cloning artifact |
| Arg -3 | - | cloning artifact |
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
| Leu 48 | His 47 | conflict |
| Thr 263 | Ala 262 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43383.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 377.4 | |
| All* | Total formula weight | 43760.8 |
