2EJR

LSD1-tranylcypromine complex

Summary for 2EJR

Entry DOI	10.2210/pdb2ejr/pdb
Related	2COM 2HKO 2IW5
Descriptor	Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE (3 entities in total)
Functional Keywords	tower domain, lsd1, fad, tranylcypromine, parnate, amine oxidase, histone, demethylase, alternative splicing, chromatin regulator, coiled coil, nucleus, oxidoreductase, phosphorylation, repressor, transcription, transcription regulation, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60341
Total number of polymer chains	1
Total formula weight	74571.97
Authors	Sengoku, T.,Mimasu, S.,Umehara, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-03-20, release date: 2008-01-01, Last modification date: 2023-10-25)
Primary citation	Mimasu, S.,Sengoku, T.,Fukuzawa, S.,Umehara, T.,Yokoyama, S. Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A Biochem.Biophys.Res.Commun., 366:15-22, 2008 Cited by PubMed: 18039463 DOI: 10.1016/j.bbrc.2007.11.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation