2C4J
Human glutathione-S-transferase M2-2 T210S mutant in complex with glutathione-styrene oxide conjugate
Summary for 2C4J
Entry DOI | 10.2210/pdb2c4j/pdb |
Related | 1HNA 1HNB 1HNC 1XW5 1YKC 2AB6 2GTU 3GTU |
Descriptor | GLUTATHIONE S-TRANSFERASE MU 2, L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE (3 entities in total) |
Functional Keywords | glutathione, glutathione transferase, transferase, m2-2, multigene family |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 4 |
Total formula weight | 104760.40 |
Authors | Tars, K.,Andersson, M.,Ivarsson, Y.,Olin, B.,Mannervik, B. (deposition date: 2005-10-20, release date: 2005-10-26, Last modification date: 2023-12-13) |
Primary citation | Norrgard, M.A.,Ivarsson, Y.,Tars, K.,Mannervik, B. Alternative Mutations of a Positively Selected Residue Elicit Gain or Loss of Functionalities in Enzyme Evolution. Proc.Natl.Acad.Sci.USA, 103:4876-, 2006 Cited by PubMed: 16549767DOI: 10.1073/PNAS.0600849103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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