2C2S
Human Dihydrofolate Reductase Complexed With NADPH and 2,4-Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, A novel boron containing, nonclassical Antifolate
Summary for 2C2S
| Entry DOI | 10.2210/pdb2c2s/pdb |
| Related | 1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 2C2T 2DHF |
| Descriptor | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE, ... (5 entities in total) |
| Functional Keywords | nonclassical antifolates, lipophilic antifolates, nadp, one- carbon metabolism, oxidoreductase, reductase |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 2 |
| Total formula weight | 44842.75 |
| Authors | Leung, A.K.W.,Reynolds, R.C.,Riordan, J.M.,Borhani, D.W. (deposition date: 2005-09-29, release date: 2007-04-10, Last modification date: 2019-05-08) |
| Primary citation | Reynolds, R.C.,Campbell, S.R.,Fairchild, R.G.,Kisliuk, R.L.,Micca, P.L.,Queener, S.F.,Riordan, J.M.,Sedwick, W.D.,Waud, W.R.,Leung, A.K.W.,Dixon, R.W.,Suling, W.J.,Borhani, D.W. Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation. J.Med.Chem., 50:3283-, 2007 Cited by PubMed: 17569517DOI: 10.1021/JM0701977 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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