1KMS
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE
Summary for 1KMS
Entry DOI | 10.2210/pdb1kms/pdb |
Related | 1KMV |
Descriptor | DIHYDROFOLATE REDUCTASE, SULFATE ION, 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, antiparasitic drugs, reductase, lipophilic antifolates |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22618.45 |
Authors | Klon, A.E.,Heroux, A.,Ross, L.J.,Pathak, V.,Johnson, C.A.,Piper, J.R.,Borhani, D.W. (deposition date: 2001-12-17, release date: 2002-07-10, Last modification date: 2024-04-03) |
Primary citation | Klon, A.E.,Heroux, A.,Ross, L.J.,Pathak, V.,Johnson, C.A.,Piper, J.R.,Borhani, D.W. Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution. J.Mol.Biol., 320:677-693, 2002 Cited by PubMed: 12096917DOI: 10.1016/S0022-2836(02)00469-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.09 Å) |
Structure validation
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