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1HFR

COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE

Summary for 1HFR
Entry DOI10.2210/pdb1hfr/pdb
DescriptorDIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, ... (4 entities in total)
Functional Keywordsoxidoreductase, one-carbon metabolism
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight22537.37
Authors
Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Blakley, R.L.,Gangjee, A. (deposition date: 1997-11-04, release date: 1998-01-28, Last modification date: 2024-02-07)
Primary citationCody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Blakley, R.L.,Gangjee, A.
Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13:307-315, 1998
Cited by
PubMed: 9627670
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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