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2BE2

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239

Summary for 2BE2
Entry DOI10.2210/pdb2be2/pdb
Related2B5J 2BAN
Related PRD IDPRD_900003
DescriptorREVERSE TRANSCRIPTASE P66 SUBUNIT, REVERSE TRANSCRIPTASE P51 SUBUNIT, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
Functional Keywordsaids, hiv, drug design, reverse transcriptase, rt, protein-inhibitor complex, drug resistance, transferase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains2
Total formula weight116187.79
Authors
Primary citationHimmel, D.M.,Das, K.,Clark Jr., A.D.,Hughes, S.H.,Benjahad, A.,Oumouch, S.,Guillemont, J.,Coupa, S.,Poncelet, A.,Csoka, I.,Meyer, C.,Andries, K.,Nguyen, C.H.,Grierson, D.S.,Arnold, E.
Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains.
J.Med.Chem., 48:7582-7591, 2005
Cited by
PubMed: 16302798
DOI: 10.1021/jm0500323
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.43 Å)
Structure validation

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