2BE2
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | VAL111 | |
| B | ASP186 | |
| B | LEU187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by viral protease => ECO:0000269|PubMed:2476069 |
| Chain | Residue | Details |
| B | PRO1 | |
| A | LEU479 | |
| A | SER499 | |
| A | LYS550 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| B | TRP402 | |
| B | GLU415 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| A | TRP402 | |
| A | GLU415 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by viral protease; partial |
| Chain | Residue | Details |
| A | TYR441 |
