2BE2
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | REVERSE TRANSCRIPTASE P66 SUBUNIT | polymer | 560 | 64501.0 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus 1 | HIV-1 RT |
2 | B | REVERSE TRANSCRIPTASE P51 SUBUNIT | polymer | 430 | 50281.8 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus 1 | HIV-1 RT |
3 | C, D | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900003) | sucrose | ||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
6 | A | 4-(3,5-DIMETHYLPHENOXY)-5-(FURAN-2-YLMETHYLSULFANYLMETHYL)-3-IODO-6-METHYLPYRIDIN-2(1H)-ONE | non-polymer | 481.3 | 1 | Chemie (R22) | |||
7 | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 430 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Ser 280 | Cys 878 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 280 | Cys 878 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 114782.7 | |
Branched | Number of molecules | 2 |
Total formula weight | 684.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 720.5 | |
All* | Total formula weight | 116187.8 |