2BE2
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | REVERSE TRANSCRIPTASE P66 SUBUNIT | polymer | 560 | 64501.0 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | HIV-1 RT |
| 2 | B (B) | REVERSE TRANSCRIPTASE P51 SUBUNIT | polymer | 430 | 50281.8 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 | HIV-1 RT |
| 3 | C, D (C, D) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900003) | sucrose | ||
| 4 | E, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | G (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 6 | H (A) | 4-(3,5-DIMETHYLPHENOXY)-5-(FURAN-2-YLMETHYLSULFANYLMETHYL)-3-IODO-6-METHYLPYRIDIN-2(1H)-ONE | non-polymer | 481.3 | 1 | Chemie (R22) | |||
| 7 | I, J (A, B) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 430 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 878 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 878 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114782.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 684.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 720.5 | |
| All* | Total formula weight | 116187.8 |
