Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2ANQ

Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a.

Summary for 2ANQ
Entry DOI10.2210/pdb2anq/pdb
Related2ANO
DescriptorDihydrofolate reductase, MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywordsdhfr, protein inhibitor complex, oxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight19242.13
Authors
Summerfield, R.L.,Daigle, D.M.,Mayer, S.,Jackson, S.G.,Organ, M.,Hughes, D.W.,Brown, E.D.,Junop, M.S. (deposition date: 2005-08-11, release date: 2006-07-25, Last modification date: 2024-02-14)
Primary citationSummerfield, R.L.,Daigle, D.M.,Mayer, S.,Mallik, D.,Hughes, D.W.,Jackson, S.G.,Sulek, M.,Organ, M.G.,Brown, E.D.,Junop, M.S.
A 2.13 A Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region
J.Med.Chem., 49:6977-6986, 2006
Cited by
PubMed: 17125251
DOI: 10.1021/jm060570v
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.13 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon