2ANQ
Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 159 | 18020.3 | 1 | UniProt (P0ABQ4) Pfam (PF00186) | Escherichia coli | |
| 2 | B, C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | D (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 4 | E (A) | (2,5-dimethylbenzene-1,4-diyl)dimethanediyl bis(N-carbamimidoylcarbamimidothioate) | non-polymer | 366.5 | 1 | Chemie (C1A) | |||
| 5 | F (A) | water | water | 18.0 | 407 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Asp 37 | Asn 37 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18020.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1221.8 | |
| All* | Total formula weight | 19242.1 |
