2ANO

Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17

Summary for 2ANO

Entry DOI	10.2210/pdb2ano/pdb
Descriptor	Dihydrofolate reductase, MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	dhfr, protein inhibitor complex, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	19096.97
Authors	Summerfield, R.L.,Daigle, D.M.,Mayer, S.,Jackson, S.G.,Organ, M.,Hughes, D.W.,Brown, E.D.,Junop, M.S. (deposition date: 2005-08-11, release date: 2006-07-25, Last modification date: 2024-02-14)
Primary citation	Summerfield, R.L.,Daigle, D.M.,Mayer, S.,Mallik, D.,Hughes, D.W.,Jackson, S.G.,Sulek, M.,Organ, M.G.,Brown, E.D.,Junop, M.S. A 2.13 A Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region J.Med.Chem., 49:6977-6986, 2006 Cited by PubMed: 17125251 DOI: 10.1021/jm060570v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.68 Å)

Structure validation