2ANO
Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17
Summary for 2ANO
Entry DOI | 10.2210/pdb2ano/pdb |
Descriptor | Dihydrofolate reductase, MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | dhfr, protein inhibitor complex, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19096.97 |
Authors | Summerfield, R.L.,Daigle, D.M.,Mayer, S.,Jackson, S.G.,Organ, M.,Hughes, D.W.,Brown, E.D.,Junop, M.S. (deposition date: 2005-08-11, release date: 2006-07-25, Last modification date: 2024-02-14) |
Primary citation | Summerfield, R.L.,Daigle, D.M.,Mayer, S.,Mallik, D.,Hughes, D.W.,Jackson, S.G.,Sulek, M.,Organ, M.G.,Brown, E.D.,Junop, M.S. A 2.13 A Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region J.Med.Chem., 49:6977-6986, 2006 Cited by PubMed: 17125251DOI: 10.1021/jm060570v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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