2A1E

High resolution structure of HIV-1 PR with TS-126

Summary for 2A1E

• Entry DOI: 10.2210/pdb2a1e/pdb
• Related: 1FGC 1S6G
• Descriptor: Pol polyprotein, DIMETHYL SULFOXIDE, SODIUM ION, ... (8 entities in total)
• Functional Keywords: hiv pr, peptidomimetic inhibitor, stereoisomer, screening a mixture, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 2
• Total formula weight: 23045.74

Authors

Demitri, N.,Geremia, S.,Randaccio, L.,Wuerges, J.,Benedetti, F.,Berti, F.,Dinon, F.,Campaner, P.,Tell, G. (deposition date: 2005-06-20, release date: 2006-02-21, Last modification date: 2023-10-25)

• Primary citation: Geremia, S.,Demitri, N.,Wuerges, J.,Benedetti, F.,Berti, F.,Tell, G.,Randaccio, L.; A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography.; Chemmedchem, 1:186-188, 2006; PubMed: 16892350; DOI: 10.1002/cmdc.200500063

Experimental method

X-RAY DIFFRACTION (1.3 Å)