29ON

Crystal structure of the staphylococcal efflux pump QacA in the inward open state in complex with nanobody 89

Summary for 29ON

• Entry DOI: 10.2210/pdb29on/pdb
• Descriptor: Antiseptic resistance protein, Nanobody 89, PHOSPHATIDYLETHANOLAMINE, ... (6 entities in total)
• Functional Keywords: multidrug efflux pump, major facilitator superfamily, mfs, dha2 family, antimicrobial resistance, drug resistance, proton-coupled transport, drug-proton antiport, membrane protein, 14-transmembrane helix, secondary active transporter, cationic substrate efflux, nanobody, single-domain indian camelid antibody
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 4
• Total formula weight: 147867.49

Authors

Jodaitis, L.,Hutchin, A.,Govaerts, C. (deposition date: 2026-03-26, release date: 2026-04-22)

• Primary citation: Jodaitis, L.,Sutton, P.,Hutchin, A.,Dashtbani-Roozbehani, A.,Martens, C.,Coppieters, K.,Pardon, E.,Steyaert, J.,O'Mara, M.,Brown, M.,Govaerts, C.; Structural and dynamic insights into the staphylococcal efflux pump QacA reveal multidrug transport mechanisms and substrate specificity determinants; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.32 Å)