29MJ

Akt1 mutant in complex with miransertib (ARQ 092)

Summary for 29MJ

• Entry DOI: 10.2210/pdb29mj/pdb
• Descriptor: RAC-alpha serine/threonine-protein kinase, 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: akt, miransertib, arq-092, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 156565.75

Authors

Depta, L.,Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2026-03-23, release date: 2026-07-01)

• Primary citation: Quambusch, L.,D'Angelo, D.,Kirschner, T.,Beerbaum, M.,Depta, L.,Schnecke, F.,Niggenaber, J.,Brandherm, S.,Weisner, J.,Mueller, M.P.,Rauh, D.; Selective covalent-allosteric tools to dissect Akt2; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)