29MJ
Akt1 mutant in complex with miransertib (ARQ 092)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | RAC-alpha serine/threonine-protein kinase | polymer | 445 | 51674.0 | 3 | UniProt (P31749) Pfam (PF00169) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha |
| 2 | D, G, I (A, B, C) | 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine | non-polymer | 432.5 | 3 | Chemie (6S1) PubChem (53262401) | |||
| 3 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | F, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 5 | J, K, L (A, B, C) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A, B, C: 2 - 446 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 114 | Glu 114 | engineered mutation |
| Ala 115 | Glu 115 | engineered mutation |
| Ala 116 | Glu 116 | engineered mutation |
| Thr 205 | Ser 205 | engineered mutation |
| Glu 262 | Asp 262 | engineered mutation |
| - | Glu 267 | deletion |
| Arg 268 | Lys 268 | engineered mutation |
| Asp 269 | Asn 269 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 155021.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1543.8 | |
| All* | Total formula weight | 156565.7 |
