29LK

High-resolution structure of human SHMT2 in complex with PLP-Ser (external aldimine)

Summary for 29LK

• Entry DOI: 10.2210/pdb29lk/pdb
• Related: 8AQL 9RWD
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
• Functional Keywords: tetrahydrofolate, one-carbon metabolism, cancer therapy target, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 213525.67

Authors

Warlich, A.,Ruszkowski, M.,Nawrot, D. (deposition date: 2026-03-20, release date: 2026-08-12)

• Primary citation: Warlich, A.,Ruszkowski, M.,Nawrot, D.; High-resolution structures of human SHMT2; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.26 Å)