29GE

Crystal structure of human METTL1 in complex with OBV617 (compound B19)

This is a non-PDB format compatible entry.

Summary for 29GE

• Entry DOI: 10.2210/pdb29ge/pdb
• Descriptor: tRNA (guanine-N(7)-)-methyltransferase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... (6 entities in total)
• Functional Keywords: mettl1, m7g, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 29944.07

Authors

Nai, F.,Bobileva, O.,Caflisch, A. (deposition date: 2026-03-10, release date: 2026-08-26, Last modification date: 2026-09-09)

• Primary citation: Nai, F.,Bobileva, O.,Caflisch, A.; Adenosine 5'-Carboxamide-Based Inhibitors of METTL1; To Be Published, 2026; DOI: 10.1021/acsmedchemlett.6c00203

Experimental method

X-RAY DIFFRACTION (2.89 Å)