29GE

Crystal structure of human METTL1 in complex with OBV617 (compound B19)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	tRNA (guanine-N(7)-)-methyltransferase	polymer	252	29178.3	1	UniProt (Q9UBP6) Pfam (PF02390)	Homo sapiens (human)	Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase
2	B (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG) PubChem (8117)
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
4	D (A)	[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]-[4-[[2,4-bis(oxidanyl)phenyl]methyl]piperazin-1-yl]methanone	non-polymer		471.5	1	Chemie (A1J17)
5	E (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	F (A)	water	water		18.0	9	Chemie (HOH)

Sequence modifications

A: 2 - 235 (UniProt: Q9UBP6)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Arg -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29178.3
Non-Polymers*	Number of molecules	4
	Total formula weight	765.7
All*	Total formula weight	29944.1

*Water molecules are not included.