28ZC

Crystal structure of the human METTL16 Methyltransferase Domain in complex with a bisubstrate analogue (BA4)

Summary for 28ZC

Entry DOI	10.2210/pdb28zc/pdb
Related	28WE
Descriptor	RNA N(6)-adenosine-methyltransferase METTL16, 1,2-ETHANEDIOL, (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7~{H}-purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid, ... (6 entities in total)
Functional Keywords	mettl16, methyltransferase, bisubstrate analogue, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34772.58
Authors	Stamm, F.,Caflisch, A. (deposition date: 2026-03-02, release date: 2026-10-14, Last modification date: 2026-10-21)
Primary citation	Stamm, F.,Wan, Z.,Vargas-Rosales, P.A.,Corbeski, I.,Braud, E.,Iannazzo, L.,Cui, Q.,Caflisch, A. Catalysis Tuned for Metabolic Sensing: Dynamics and Mechanism of the RNA Methyltransferase METTL16 Rsc Chem Biol, 2026 Cited by DOI: 10.1039/D6CB00242K PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation